Award details

Reasoning with uncertainty in genome annotation using argumentation

Reference	BIO14405
Principal Investigator / Supervisor	Professor Michael Sternberg
Co-Investigators / Co-Supervisors	Professor John Fox
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	158,572
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/12/2004
Duration	40 months

Abstract

To develop, benchmark and apply a computer system to manage the uncertainty reasoning required for automated annotation of possible functions of protein coding region of genomes. Possible suggestions of gene function will be taken from various bioinformatics data sources (homology, motifs, pathway and the literature). Reasoning will be managed using a novel logic-based argumentation approach that combines quantitative, semi-quantitative (approximate) and qualitative forms of uncertainty. The system will be applied to model genomics. The results will be accessible via the WWW and incorporate an explicit representation of the justifications (arguments) for alternative annotations suitable for the biological end user.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Bioinformatics (Phase 2) (BIO) [1998-2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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