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Genome analysis using DNA structure
Reference
BIO14258
Principal Investigator / Supervisor
Professor Christopher Hunter
Co-Investigators /
Co-Supervisors
Professor Peter Willett
Institution
University of Sheffield
Department
Chemistry
Funding type
Research
Value (£)
134,164
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2004
Duration
36 months
Abstract
We have developed a collective variable approach which allows us to rapidly build accurate, high resolution structures of double helical DNA. The aim is to develop tools to apply this method to the analysis of genome sequences. There are two aspects: to construct a database of the structural properties of all possible DNA decamers; and to develop similarity searching tools to analyse this database. This will enable us to uncover hidden patterns in genomic sequences which are encoded in the structural properties and to develop structural templates which can be used to search for specific properties in a given sequence.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Bioinformatics (Phase 2) (BIO) [1998-2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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