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Detecting mosaic sequences and rate heterogeneity in phylogenetic datasets
Reference
BIO10494
Principal Investigator / Supervisor
Dr Francis George Wright
Co-Investigators /
Co-Supervisors
Dr David Marshall
,
Dr Glenn Rowe
Institution
The James Hutton Institute
Department
Biomathematics and Statistics Department
Funding type
Research
Value (£)
123,748
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
01/04/2003
Duration
42 months
Abstract
We propose to improve methods and software for the detection of evidence of recombination (i.e. presence of mosaic sequences) in molecular sequence alignments. There are three aspects to the statistical methodology: (1) improvements to existing methods especially to remove the influence of among-site rate variation, (2) the addition of a statistical test to the existing graphical method, and (3) the testing of new statistic based on a Hidden Markov Model to analyse subsets of sequences and the development of an algorithm to combine the results of the analyses on subsets. All these methods will be programmed in the Java language to provide user-friendly and portable code.
Summary
unavailable
Committee
Not funded via Committee
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Bioinformatics (Phase 2) (BIO) [1998-2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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