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Automated analysis of gene sequence data banks to reveal the evolutionary and population responses for genetic diversity

Reference	BIF05332
Principal Investigator / Supervisor	Professor P Harvey
Co-Investigators / Co-Supervisors	Professor Edward Holmes, Dr Sean Nee
Institution	University of Oxford
Department	Zoology
Funding type	Research
Value (£)	109,927
Status	Completed
Type	Research Grant
Start date	01/10/1996
End date	01/04/2000
Duration	42 months

Abstract

To produce an integrated, user friendly and interactive computer application which allows users to align sequences, reconstruct phylogenetic trees of genalogies from those sequences using variable and maximum likelihood methods, and analyse the branching structure of trees obtained in order to make inferences about underlying evolutionary and population processes. The computer application will incorporate recently developed methods for 1) identifying areas of trees with unusual rates of branching, 2) estimating per lineage speciation and extinction or birth and death rates, 3) identifying macroevolutionary events such as mass extinctions when the sequences represent a complete sample of extant species from a clade, and 4) revealing the dynamical history of populations when the sequences are from a sample of individuals collected from a population.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Bioinformatics (BIF) [1995-1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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