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Role of the Cpx regulon in S. typhimurium physiology and virulence
Reference
BFP11355
Principal Investigator / Supervisor
Professor Mark Roberts
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary Infection and Immunity
Funding type
Research
Value (£)
216,662
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
01/04/2003
Duration
48 months
Abstract
The response to extracytoplasmic stress (ES) in Gram negative bacteria is controlled by 2 separate signal transduction pathways. One pathway is controlled by the alternative sigma factor, RpoE, and the second is mediated by the Cpx two-component system. The purpose of this study is to investigate the role the Cpx system plays in Salmonella physiology and virulence and immunity. S. typhimurium strains with mutations in genes in the Cpx regulon will be constructed. These strains will be used to investigate the involvement of the S. typhimurium Cpx system in gene regulation, general physiology, adaptation to different environments, stress defence, interaction with eukaryotic cells, virulence, pathogenesis and immunity. The interaction between the two ES response systems in the adaptation of S. typhimurium to stress and life in vivo will also be examined.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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