Award details

Respiration and oxygen tolerance in Campylobacter coli and C. jejuni: implications for food safety and colonisation

Reference	BFP11346
Principal Investigator / Supervisor	Professor Robert K Poole
Co-Investigators / Co-Supervisors	Dr Simon Park, Dr Guanghui Wu
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	364,925
Status	Completed
Type	Research Grant
Start date	01/07/1999
End date	13/11/2002
Duration	40 months

Abstract

This project seeks to understand for the first time the responses to oxygen of campylobacters - food-borne, microaerophilic pathogenic bacteria - and thus provide underpinning knowledge for developing strategies to reduce Campylobacter survival in foods and during food-processing. The following questions will be answered. (a) What are the effects of different gaseous environments on survival of campylobacters and how do cells respond at gene and protein levels to elevated or lower oxygen tensions? (b) What are the routes for respiratory electron transfer to oxygen and which are essential for survival in the various environments encountered by campylobacters? (c) What is the molecular/biochemical basis of microaerophily in campylobacters? (d) What are the virulence potential and survival characteristics of mutants selected for their altered response to oxygen?

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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