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The molecular basis of acid habituation in commensal and pathogenic Escherichia coli

Reference	BFP11341
Principal Investigator / Supervisor	Professor Ian Booth
Co-Investigators / Co-Supervisors	Dr Phillip Cash
Institution	University of Aberdeen
Department	School of Medical Sciences
Funding type	Research
Value (£)	300,545
Status	Completed
Type	Research Grant
Start date	15/08/1999
End date	16/04/2003
Duration	36 months

Abstract

Food-borne pathogens have the ability to adapt to mildly acidic conditions, such that their survival of extreme acid pH is greatly enhanced (habituation or adaptive acid tolerance response). The gene products required for survival at acid pH are largely unknown. Recent work in the applicants laboratory has shown that there is considerable variation in the intrinsic acid tolerance among commensal and O157:H7 E. coli. In addition we have shown that there is considerable heterogeneity in the acid tolerance of exponentially-growing cultures, such that a proportion always survives acid pH. This project seeks to apply proteomics and genomics to define the essential protein and RNA components of acid tolerance and their role in generating intra-strain and inter-strain heterogeneity.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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