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Structural studies of host-cell/pathogen adhesion in enteric bacterial infection
Reference
BFP11329
Principal Investigator / Supervisor
Professor Steve Matthews
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
167,470
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
01/01/2003
Duration
38 months
Abstract
Pathogenic bacteria including enterohemorrhagic E. coli O157:H7, are an emerging family of pathogens that remain an important cause of human disease in both developing countries and the western world. Structural studies of pathogen adhesion to eukaryotic cells is crucial to the understanding of disease progression. We propose to use nuclear magnetic resonance (NMR) to determine the three-dimensional structures of pathogenic bacterial cell-binding domains. We will use atomic resolution information, combined with data from site-directed mutagenesis and functional studies to characterise the cell-binding mechanism. This work will provide potent new insight into the pathogenesis of enteric bacteria.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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