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Secreted effector proteins of Salmonella: structure functions and their role in virulence
Reference
BFP11326
Principal Investigator / Supervisor
Dr Edouard Galyov
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Molecular Biology Pirbright
Funding type
Research
Value (£)
151,597
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
01/11/2002
Duration
36 months
Abstract
This study will investigate the Salmonella proteins that are likely to be involved in colonisation of the gastrointestinal tract and the induction of enteritis in humans and farm animals. The role(s) of S. dublin secreted effector proteins (Sops) in these processes will be assessed. Proposed experiments include: i) cloning, sequencing, and mutagenesis of S. dublin sopA and sopD genes; ii) raising anti-Sop antibodies; iii) analysis of Sops localisation and their role in Salmonella - eukaryotic cell interactions; and iv) analysis of the role of Sop proteins for S. dublin virulence in cattle and in mice.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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