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The development of a novel mucosal immunisation strategy for the control of foodborne pathogens
Reference
BFP11298
Principal Investigator / Supervisor
Dr John Huntley
Co-Investigators /
Co-Supervisors
Dr David Buxton
,
Professor Willie Donachie
,
Dr Neil Foster
Institution
Moredun Research Institute
Department
Vaccines and Diagnostics
Funding type
Research
Value (£)
146,534
Status
Completed
Type
Research Grant
Start date
04/10/1999
End date
04/04/2003
Duration
42 months
Abstract
The objective is to develop an effective vaccination strategy of stimulating the local mucosal immune system of sheep. Antigen delivery will be via biodegradable poly(D,L-lactide-co-glycolide) (PLG) microspheres targeted via lectins to absorptive cells (M cells) or enterocytes within the follicle associated epithelium of ovine Peyer's patches. Initial studies will determine those lectins which bind preferentially to receptors on M cells/enterocytes within bronchial, jejunal or ileal Peyer's patches, and these will be incorporated into the PLG's for intranasal or oral administration. Proteins from two important foodborne pathogens, namely listeriolysin from Listeria monocytogenes and SAG 1 from Toxoplasma gondii will be employed to evaluate the vaccines.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Food-Borne Pathogens (BFP) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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