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Modulation of the bc12-regulated cell death pathway using peptide-based ligands

Reference	BCI06295
Principal Investigator / Supervisor	Professor John Coggins
Co-Investigators / Co-Supervisors
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	63,651
Status	Completed
Type	Research Grant
Start date	15/03/1996
End date	15/09/1997
Duration	18 months

Abstract

We have recently identified an uncharacterised outer mitochondrial membrane protein (BIC) which interacts directly with the N-terminal domain of the anti-cell death protein bc12. We propose to study the nature of this interaction at the molecular level with the aim of designing peptide-based ligands which can mimic the binding of bc12 to BIC such that cell death is induced or repressed. The nature of the interactions between various members of the bc12 family of cell death activators and repressors will be used to identify elements useful in the design of these ligands and their activities monitored by in vivo and in vitro cell death assays. Ligands which modulate cell death may have therapeutic value for a variety of diseases.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biological Chemistry Initiative (BCI) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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