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The role of glycosylation and carbohydrate structure in molecular recognition events which mediate quality control in the endoplasmic reticulum
Reference
BCI06290
Principal Investigator / Supervisor
Professor Stephen High
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
158,297
Status
Completed
Type
Research Grant
Start date
01/09/1996
End date
01/09/1999
Duration
36 months
Abstract
Newly synthesised glycoproteins with N-linked carbohydrate side chains bind a subset of ER proteins which behave as molecular chaperones. Binding to these components is dependent upon glycosylation and influenced by the exact nature of the carbohydrate side chain. This process may be the basis for imposing a quality control stage during glycoprotein biosynthesis. The project will analyse glycosylation specific molecular interactions by cross-linking. ER proteins which bind specifically to glycoproteins will be identified and the importance of carbohydrate side chain composition analysed. The mechanisms which regulate binding and release will be determined and the effect of glycosylation upon protein secretion in vivo will be addressed.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biological Chemistry Initiative (BCI) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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