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Temperature-dependent raman optical activity studies of proteins

Reference	BCI06235
Principal Investigator / Supervisor	Professor Laurence Barron
Co-Investigators / Co-Supervisors	Dr Lutz Hecht
Institution	University of Glasgow
Department	School of Chemistry
Funding type	Research
Value (£)	193,915
Status	Completed
Type	Research Grant
Start date	25/11/1996
End date	25/11/1999
Duration	36 months

Abstract

New spectrograph and detector technology will be incorporated into the second Glasgow ROA instrument which will then be dedicated to novel studies of the dynamic aspects of protein structure by measuring ROA spectra over the temperature range 0-80oC. Attempts will be made to detect and characterise tertiary folds in molten globule states, disorder-to-order transitions in native states, and nascent structure in unfolded states. The results will be used to enhance our understanding of protein folding and function.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biological Chemistry Initiative (BCI) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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