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The coordination chemistry of the cofactor of oxomolybdoenzymes tunzymes and analogues

Reference	BCI06193
Principal Investigator / Supervisor	Professor Christopher Garner
Co-Investigators / Co-Supervisors	Dr David Collison
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	135,823
Status	Completed
Type	Research Grant
Start date	01/09/1996
End date	31/08/1999
Duration	36 months

Abstract

The total synthesis of the metal-containing cofactors Moco of the oxomolybdoenzymes and Tuco of the tunzymes is proposed. The synthesis of molybdopterin (MPT) is underway at Manchester but the synthesis of metal-oxo-complexes with one and two MPT per metal remains a major challenge. Strategies for this coordination chemistry will be developed and products characterised structurally, electrochemically and spectroscopically (e.g. XAS, EPR, ENDOR, ESEEM, NMR). The synthetically-derived cofactors will be incorporated into Mo and W apoproteins, especially for isotopic labelling of MPT for spectroscopic studies of intermediates in the catalytic cycle. Isolation of MPT trapped by a suitable metal centre will be attempted for full characterisation.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biological Chemistry Initiative (BCI) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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