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New methods and strategies for oligosaccharide assembly
Reference
BCI06178
Principal Investigator / Supervisor
Professor Steven Ley
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
280,750
Status
Completed
Type
Research Grant
Start date
01/09/1996
End date
01/01/2000
Duration
40 months
Abstract
To investigate new protecting groups and novel reactivity control strategies for the synthesis of complex oligosaccharide arrays. We have developed the CyclohexaneDiAcetal group which shows good selectivity for transdiequatorial 1,2 diols.We will prepare chiral CDA protecting groups, which we expect to show enhanced selectivity in protection reactions where there are two pairs of diols and take part in desymmetrisation using the principles of chirality matching and mis-matching. We will also investigate new deprotection strategies. Our goal is to develop CDA protecting groups that may be removed using a variety of different reagent systems. We will combine our multiple sequential glycosidation strategy using reactivity tuning of the glycoside donors with orthogonal glycosidation to allow large saccharide blocks to be assembled quickly and efficiently.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biological Chemistry Initiative (BCI) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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