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Structure and interactions of the gene regulatory protein AreA of Aspergillus nidulans
Reference
BCI04942
Principal Investigator / Supervisor
Professor Geoff Kneale
Co-Investigators /
Co-Supervisors
Institution
University of Portsmouth
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
177,457
Status
Completed
Type
Research Grant
Start date
23/08/1995
End date
23/02/1999
Duration
42 months
Abstract
We have cloned, over-expressed and purified the gene regulatory protein AreA, and shown that the protein binds specifically to a DNA sequence from the A. nidulans genome. We now wish to (i) determine the range of DNA operator sites to which AreA binds, and probe the protein-DNA interactions at these sites (ii) initiate studies of the 3-D structure of AreA and appropriate DNA-protein complexes (iii) investigate the mechanism of transcriptional repression by measurements of the affinity of AreA for specific sites and the modulation of DNA binding by co-factors.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biological Chemistry Initiative (BCI) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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