Award details

The structure and function of MerT, the mercuric ion transport protein of transposon Tn501

Reference	BCI04148
Principal Investigator / Supervisor	Professor Nigel Brown
Co-Investigators / Co-Supervisors	Dr Andrew Morby
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	146,851
Status	Completed
Type	Research Grant
Start date	17/07/1995
End date	17/07/1998
Duration	36 months

Abstract

The mercuric ion transport protein MerT from transposon Tn501 is sufficient for transport of HgII across the bacterial cytoplasmic membrane in Gram-negative bacteria. The MerT protein is an essential component of the mercuric ion resistance system, which is of potential use in bioremediation by removal of HgII from contaminated waters and soils. We propose to test our model of mercuric ion resistance and to improve understanding of the molecular mechanism of resistance by investigating the topology, the mercury-specificity of the MerT protein, by studying interactions of MerT with other proteins, and by isolating and similarly characterising specific mutants of MerT.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biological Chemistry Initiative (BCI) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

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