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Synthesis, conformational stability and properties of cis-peptidyl prolinamides
Reference
BCI03817
Principal Investigator / Supervisor
Professor David Gani
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
143,728
Status
Completed
Type
Research Grant
Start date
01/09/1995
End date
01/09/1998
Duration
36 months
Abstract
Using our recently developed synthetic methodology which provides access to cis-peptidyl prolinamides of the type H-Xaa-Pro-NH2 (for the first time) we wish to prepare variants and study their conformational stability with respect isomerisation. These experiments (kinetic and thermodynamic measurement) will be performed in a range of solvents and under conditions of varying pH and ionic strength. The information is important in understanding peptide structure and function and how proteins fold.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biological Chemistry Initiative (BCI) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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