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Fluidised bed adsorbents for selective recovery of plasmid vectors designed for gene therapy
Reference
BCE08082
Principal Investigator / Supervisor
Professor Andrew Lyddiatt
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Chemical Engineering
Funding type
Research
Value (£)
224,742
Status
Completed
Type
Research Grant
Start date
01/01/1998
End date
01/02/2001
Duration
37 months
Abstract
The key objective is the advancement of a scaleable unit operation (fluidised bed adsorption) specifically tailored for the primary extraction, concentration and purification of plasmid DNA exploiting procedures compatible with commercial practice and the specifications of sterile, injectable pharmaceuticals. Milestones will incude the physical characterisation of prototype adsorbents in various contactor configurations, the definition of the influence of particle geometry upon adsorption/desorption performance, the development of advanced selective chemistries to exploit specific adsorption/desorption phenomena, and the maintenance of operational longevity of assemblies in extended use. Prototype designs and assemblies will be established for selective recovery (at commercial scales) of plasmid particles facilitated by direct adsorption from viscous and particulate feedstocks.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Biochemical Engineering (BCE) [1993-1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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