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Investigation of supercritical fluid technology to produce dry particulate formulations of proteins

Reference	BCE07404
Principal Investigator / Supervisor	Professor P York
Co-Investigators / Co-Supervisors	Dr William Ashraf, Professor Mike Hoare
Institution	University of Bradford
Department	Pharmacy
Funding type	Research
Value (£)	300,883
Status	Completed
Type	Research Grant
Start date	14/04/1997
End date	14/04/2000
Duration	36 months

Abstract

The study aims to evaluate the utility of a new technology based on supercritical fluids to produce stable, dry protein and DNA powders. There are two main thrusts; an investigation of the utility of the technique with various proteins (unrestricted availability as well as company-specific), and an in depth analysis of the effects of SEDS processing on macromolecule stabilisation from a processing viewpoint. The ultimate objective is to provide the fundamental understanding to underpin scale-up of the SEDS process for biologicals.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Biochemical Engineering (BCE) [1993-1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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