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Award details
Synthesis of primary downstream processing procedures for recombinant herpes virus vaccines
Reference
BCE07400
Principal Investigator / Supervisor
Professor Nigel Slater
Co-Investigators /
Co-Supervisors
Institution
Aston University
Department
Sch of Engineering and Applied Science
Funding type
Research
Value (£)
57,368
Status
Completed
Type
Research Grant
Start date
01/11/1996
End date
01/11/1998
Duration
24 months
Abstract
Viral vaccines will give immunisation against debilitating illnesses provided engineering principles are established for the rational synthesis of manufacturing processes. This LINK project focuses on primary downstream processing procedures. It would (1) characterise the parameters that influence post-harvest release of viruses, (2) devise cell homogenisation procedures permitting optimal recovery of infective virus and low release of geonomic DNA, and (3) establish the principles which underpin the membrane separation of viruses from cells, cell debris and macromolecules, characterise fractionation efficiency and define membrane processing procedures. The project will deliver scale relationships for use by Cantab Pharmaceuticals Research Ltd. for process validation.
Summary
unavailable
Committee
Closed Committee - Engineering & Biological Systems (EBS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Biochemical Engineering (BCE) [1993-1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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