Award details

Metabolic engineering of triterpenoid pathways involved in plant defense in Arabidopsis and rice

Reference	BBS/E/J/000CA516
Principal Investigator / Supervisor	Professor Anne Osbourn
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	118,712
Status	Completed
Type	Institute Project
Start date	04/03/2013
End date	03/03/2015
Duration	24 months

Abstract

Plants produce a diversity array of natural products (secondary metabolites) that have important ecological functions. Triterpenes are one of the largest classes of plant-derived natural products. They protect plants against pests and diseases and are also important as drugs and anticancer agents. Arabidopsis and cereals such as rice do not make protective triterpene glycosides. These species are therefore excellent experimental systems for proof-of-concept experiments involving metabolic engineering of triterpene pathways into heterologous species. The aim of this proposal is to engineer triterpene metabolic pathways into Arabidopsis and rice by genetic modification, using recombineering and synthetic biology. At the end of this project we will have the necessary knowledge to devise strategies to introduce multiple genes into diverse plant species for control of plant pests and diseases based on synthesis of protective triterpenes.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Crop Science, Plant Science, Synthetic Biology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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