BBSRC Portfolio Analyser
Award details
Transcriptional characterization of the inviability
Reference
BBS/B/07705
Principal Investigator / Supervisor
Professor Michael Ashburner
Co-Investigators /
Co-Supervisors
Dr Jose Ranz
Institution
University of Cambridge
Department
Genetics
Funding type
Research
Value (£)
435,625
Status
Completed
Type
Research Grant
Start date
19/04/2004
End date
18/09/2007
Duration
41 months
Abstract
When Drosophila melanogaster and Drosophila simulans are crossed, one sex of the progency is sterile and the other is inviable. The former exhibits external malformations; the latter dies either as embryos or larvae. The phenotypes of the hybrids are the result of genetic incompatibilities that have accumulated since the divergence, some 2.5Myr ago, between the parent species. We will use cDNA microarrays to compare the expression profile of genes in the hybrids with those of the parental species. This will allow is to assess the extent of regulatory incompatibility between two recently diverged genomes. It will also allow us to estimate the regulatory and metabolic targets that are associated with the functional divergence of these species.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search