Award details

14 ERA-CAPS: INvestigating TRiticeae EPIgenomes for Domestication (INTREPID)

Reference	BBS/E/T/000GP091
Principal Investigator / Supervisor	Professor Anthony Hall
Co-Investigators / Co-Supervisors	Professor Neil Hall
Institution	Earlham Institute
Department	Earlham Institute Department
Funding type	Research
Value (£)	53,240
Status	Completed
Type	Institute Project
Start date	01/10/2016
End date	31/03/2017
Duration	5 months

Abstract

Plant breeding uses DNA sequence variation to make new allelic combinations for crop improvement. Our creation of the first wheat gene sequence assemblies (Brenchley et al Nature 491, 705) has enabled new levels of high throughput precise genotyping for breeding this globally important crop. Nevertheless, there are other levels of heritable variation, such as epigenetic modifications, that are widely thought to play a key role in shaping genomes and creating new variation. We have recently developed highly efficient re-sequencing technologies for wheat that can measure DNA methylation in genes of multiple lines. This provides an outstanding opportunity to assess epigenetic variation in a major polyploid crop and understand how it may influence traits. The overall objective of this proposal is to use newly available wheat genome resources, together with our innovative application of exome capture and bisulphite sequencing, to measure epigenetic modifications in wheat genes, and relate these to gene expression and the acquisition of new phenotypes, and how they may contribute to genetic changes such as gene loss during polyploid formation.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Crop Science, Plant Science
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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