Award details

Genetic control of immune responsiveness in cattle

ReferenceBBS/E/R/04780647
Principal Investigator / Supervisor Professor Elizabeth Glass
Co-Investigators /
Co-Supervisors
Institution The Roslin Institute
DepartmentThe Roslin Institute Department
Funding typeResearch
Value (£) 1,168,497
StatusCompleted
TypeInstitute Project
Start date 01/04/1999
End date 31/03/2003
Duration48 months

Abstract

Polymorphism in the major histocompatibility complex (MHC) modulates immune responses through variable binding of antigenic peptides. We have developed a model system for MHC class II structure-function analysis using cattle characterised for distinct immune responses to a peptide antigen (FMDV15). The influence of MHC polymorphism on the T cell responses seen in these cattle will be analysed using transfectants and transgenic mice expressing cloned class II DR and DQ genes . In related projects we will be mapping the cattle MHC, and investigate variation in MHC polymorphism and immune response to vaccination in a large crossbred resource herd (RoBogen). These studies will allow the contribution of MHC and other loci to be evaluated in a relevant cattle population.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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