Award details

Comparative genomics with emphasis on the pig

Reference	BBS/E/R/04780628
Principal Investigator / Supervisor	Professor Alan Archibald
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	397,347
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/2000
Duration	36 months

Abstract

The aim is to exploit comparative genome analysis in the isolation and characterisation of trait genes in the farmed animal species, especially the pig. Comparative genomics is being addressed on three levels: through improving the gene content of the pig genome maps, comparative genome analysis in silico and using transgenic mice to evaluate candidate (livestock) trait genes. A comparative positional candidate gene approach will be an effective strategy for identifying trait genes in livestock. The necessary high resolution pig gene maps will be established with whole genome radiation hybrids. The comparison of gene maps across species will be effected with new databases and bioinformatic tools. Finally, comparative genomics provides a means of characterising (trait) genes once they have been identified. Transgenic mice in which candidate (livestock) trait genes have been manipulated may be particularly effective models for pigs as both species are monogastrics and have litters of multiple offspring. This project contributes to 1) the BBSRC's strategic plan objective to study (plant and) animal genetics complementing PAGA funded projects in pig genome mapping and 2) the priorities for gene mapping, identification, isolation, and characterisation within the Agricultural Systems Directorate's theme on 'Technologies for Improvement of Crops and Livestock', particularly, the development of high resolution gene maps for the farmed animal species. The project also addresses priorities identified by Technology Foresight in respect of the need to improve efficiency and uptake of new technologies (Agriculture, Natural Resources and Environment) and to exploit the opportunities offered by molecular genetics (Health and Life Sciences).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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