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QTL for components of growth in the mouse: their identification and analysis
Reference
BBS/E/R/04780623
Principal Investigator / Supervisor
Professor Grahame Bulfield
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
109,369
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/1998
Duration
12 months
Abstract
Both the Technology Foresight ANRE and the BBSRC's Genes and Developmental Biology Committee recommended the exploitation of genome mapping to understand and manipulate the biology of the whole organism. Growth is a major trait of commercial importance and we are using the mouse as a model species to identify the QTL and trait-genes' controlling it. Candidate genes could then be exploited in commercial livestock breeding programmes. (a) Continue the analysis of the QTL for growth which we have found in the X-lines of mice by making congenic lines and developing strategies to clone the genes. (b) Extend the analysis to further lines selected for fat content from a mixed population over 40 generations and which differ 5-4 fold (the F-lines). The F-line analysis is not only of interest in itself but relates to the pig and poultry QTL experiments where fat content is a potential trait and to the interest in genes affecting fat content (and resulting diabetes) in humans. (c) Positional cloning of the murine high growth (hg) locus that causes a major increase in postnatal growth. Upon cloning of hg in mice, the counterpart gene will be isolated in humans and domestic animal species.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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