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Milk protein gene expression and chromatin structure

Reference	BBS/E/R/04780616
Principal Investigator / Supervisor	Professor Christopher Whitelaw
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	337,794
Status	Completed
Type	Institute Project
Start date	01/04/1997
End date	31/03/1999
Duration	24 months

Abstract

Regulation of gene expression is essential for animal development and survival. Controlled gene expression is dependent on the structure of the chromatin template. Using the mammary gland as a model for developmentally regulated gene expression, we address fundamental questions regarding the regulation of animal gene expression in the context of the chromatin environment. We compare changes in chromatin structure with the expression state of mammary-specific genes in natural (endogenous genes) or ectopic (transgenes) chromosomal locations. Both local nucleosomal and higher-order chromatin organisation are assessed in association with loss-of-function studies in transgenic mice in vivo. Since increasing our understanding of chromatin will enable improvements to the design of transgenes, this work underpins the BBSRC Genes and Developmental Biology science-led programme and associated Directorates by addressing the Technology Foresight key priority of Genetic and Biomolecular Engineering. Three national and 5 international collaborations have been established to facilitate these and applied projects to target antibody expression to milk and enhance neuronal transgene expression. This work will output scientific peer-reviewed and general publications, and national and international grant proposals. Intellectual property relating to the exploitation of genetic modification of animal tissues, will be licensed to the UK transgenic biotechnology companies, including PPL Therapeutics.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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