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Functional genomics of avian reproductive neuroendocrinology
Reference
BBS/E/R/03780667
Principal Investigator / Supervisor
Professor Peter Sharp
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
341,613
Status
Completed
Type
Institute Project
Start date
01/04/2002
End date
31/03/2004
Duration
24 months
Abstract
The objective of this proposal is to increase understanding of neuroendocrine mechanisms that depress the function of gonadotrophin releasing hormone neurones in poultry. The ARK genomics chicken neuroendocrine hypothalamic cDNA microarray will be expanded by the addition of cDNAs derived from the chicken hypothalamus enriched to represent genes involved in the depression of GnRH neuronal function. These will be obtained from a subtractive hypothalamic EST library derived from laying and incubating hens. A profile of genes showing changes in expression will be obtained by interrogating the microarray using labeled cDNA representing hypothalamic mRNA from laying and incubating hens QTL for incubation behaviour will be identified and comparative genomics will be used to establish whether genes showing changes in expression on the microarray are present at the QTL.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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