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Neurobiology in prolactin in poultry

Reference	BBS/E/R/03780641
Principal Investigator / Supervisor	Professor Peter Sharp
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	628,181
Status	Completed
Type	Institute Project
Start date	01/03/1998
End date	31/03/2002
Duration	49 months

Abstract

The objective of this project is to increase the understanding of the central functions and control of prolactin secretion in poultry. Prolactin receptor is widespread in peripheral and central tissues and consequently changes in prolactin secretion influence many production traits. The work will use two models of prolactin function and secretion in bantams: i) incubation (broody) behaviour and ii) photoperiodic control. Molecular techniques will be used to establish the functions of prolactin receptor in the hypothalamus and to evaluate the functional significance of prolactin produced within the brain. A range of neurobiological techniques will identify neural pathways and mechanisms which stimulate increased prolactin secretion at the onset of incubation and photoperiodic stimulation which inhibit prolactin release after prolonged photostimulation. Differential display PCR will be used to identify genes expressed in the basal hypothalamus whose expression increases in association with the increase in prolactin release which occurs during exposure to one long day.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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