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The intigration of intraovarian mechanisims and endocrine signals in the regulation of ruminant ovarian follicle growth

Reference	BBS/E/R/03780639
Principal Investigator / Supervisor	Dr David Armstrong
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	391,503
Status	Completed
Type	Institute Project
Start date	01/04/1998
End date	31/03/2002
Duration	48 months

Abstract

The objective of this project is to increase our knowledge of the role of the intraovarian IGF system in regulating gonadotrophin-stimulating follicle development in ruminants. The programme of work addresses three aspects of folliculogenesis: (i) what is the role of the ovarian IGF system in the devlopment and maintenance of follicular dominance in ruminants? (ii) during the development of follicula dominance what mechanisms are involved in the inhibition of subordinate follicle growth? and (iii) how do these independant mechanisms interact to produce a single and multiple ovulations per cycle in cattle and sheep respectively. The work will make use of recently developed in vivo and in vitro ruminant model systems and involves the integration of whole animal studies with cellular and molecular mechanisms.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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