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Role of DNA Methylation as a determinant of successful epigenetic reprogramming by nuclear transfer
Reference
BBS/E/R/01800848
Principal Investigator / Supervisor
Professor Ian Wilmut
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
111,247
Status
Completed
Type
Institute Project
Start date
01/10/2000
End date
30/09/2003
Duration
36 months
Abstract
Nuclear transfer using differentiated mammalian cells requires reprogramming of all lineage-specific epigentic modifications for viable offspring to result. The likely role of DNA methylation in the reprogramming process will be investigated in the sheep, where changes in DNA methylation during embryogenesis have not been studied. An understanding of the regulation and possible deregulation of DNA methylation in this species will have important implications for improving the efficiency and the normality of nuclear transfer for both indirect (through animal products) and direct (through human cell-based therapies) healthcare applications. We will examine methylation in donor cells, oocyte cytoplasm, normal and reconstructed embryos.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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