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Isolation and characterization of stem cell-derived human somatic progenitor cells for therapeutic application.

ReferenceBBS/E/R/01780666
Principal Investigator / Supervisor Dr James McWhir
Co-Investigators /
Co-Supervisors
Institution The Roslin Institute
DepartmentThe Roslin Institute Department
Funding typeResearch
Value (£) 163,891
StatusCompleted
TypeInstitute Project
Start date 01/04/2002
End date 31/03/2006
Duration48 months

Abstract

Two of the immediate challenges in the development of human ES transplantation therapy are (1) characterization of progenitor cells for therapeutically relevant lineages and (2) development of defined culture media. (1)Functional engraftment in many applications will require transplantation of progenitor cells which subsequently differentiate in vivo. We propose to develop a general strategy for identification and purification of progenitor cells which we will exemplify in osteogenesis. (2) The present culture regime for hES cells involves the use of conditioned medium. We also seek to identify the factor(s) in conditioned medium which maintain the undifferentiated state. Finally, a component of the present proposal is to support the management of existing programmes within the group.

Summary

unavailable
Committee Closed Committee - Genes & Developmental Biology (GDB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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