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Control of differentiation in stem cells
Reference
BBS/E/R/01780664
Principal Investigator / Supervisor
Dr Thomas Burdon
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
149,484
Status
Completed
Type
Institute Project
Start date
29/01/2002
End date
31/03/2002
Duration
2 months
Abstract
Efficient propagation of pluripotent embryonic stem (ES) cells in vitro is essential for their utility in medicine and biotechnology. To identify the molecular mechanisms that regulate this process, we will study regulation of ES self- renewal by the cytokine receptor gp130. We plan to identify signals and targets downstream of gp130 that regulate the survival and differentiation of mouse ES cells. Studies will initially focus on actions of the cytokine-induced transcription factor STAT3 and a novel ES cell-specific variant of the adaptor protein Gab1. Further functional analysis of these molecules in human ES cells should facilitate the identification of conserved mechanisms regulating ES cell self-renewal.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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