Award details

Transgenic biology of the mammary gland.

Reference	BBS/E/R/01780646
Principal Investigator / Supervisor	Professor Christopher Whitelaw
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	708,828
Status	Completed
Type	Institute Project
Start date	01/04/1999
End date	31/03/2003
Duration	48 months

Abstract

Transgenic biology provides a unique approach to unravel the mechanisms involved in regulating gene expression, since mutations can be introduced into the germline of animals allowing the consequence of the mutation to be analysed in the whole animal. We will exploit this capability to investigate the role of chromatin remodelling in gene expression. Only with a full understanding of how a gene is regulated within a chromosomal environment will we be able to effectively manipulate this environment in gene transfer applications. In addition, we will use (and build on) our expertise in targeting transgene expression, and the resource of transgenic skills available at Roslin, to ask questions regarding differentiation and metabolism in vivo, focusing on the perturbation of mammary gland function in the whole animal.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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