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Cellular and molecular factors influencing development of embryos reconstructed by nuclear transfer
Reference
BBS/E/R/01780636
Principal Investigator / Supervisor
Professor Ian Wilmut
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
425,187
Status
Completed
Type
Institute Project
Start date
01/04/1997
End date
31/03/2000
Duration
36 months
Abstract
The objective is to improve methods of nuclear transfer by increasing understanding of cellular and molecular mechanisms that regulate development. The development of cloned embryos is influenced by cell cycle stage of donor cell and recipient egg. The optimal combination of cell cycle stages will be defined in greater detail after the development of novel methods for the selection of cells in specific stages. Comparisons will also be made between different donor cell types, including cells derived from embryo, fetal and adult tissues. These observations will provide a basis for future molecular analyses of factors regulating chromatin structure and gene expression after nuclear transfer.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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