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Mechanisms of initiation of skeletal mineralisation

Reference	BBS/E/R/00003741
Principal Investigator / Supervisor	Professor Colin Farquharson
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	114,167
Status	Completed
Type	Institute Project
Start date	15/09/2006
End date	31/08/2011
Duration	60 months

Abstract

We will test this hypothesis by affecting the first and second steps of MV-mediated minerlisation using a genetuc and pharmacological approach. Experimentally we will characterize the mineralisation abnormalities and related metabolic changes in mice deficient in PHospho 1 expression compared to AKp2 mice and assess the effect of the simultaneous inactivation of the Ohosph1 and Akp2 genes on skeletal minerlisation. we will also study the effects of ablating or inhibiting OHOSPHO1 and/or TNAP activity on the ability of osteoblast-derived MVs to initiate and propagate derived MVs to initiate and propagate calcification in vitro. Our work will provide fundamental insights into the mechanisms of normal bone minerlisation. Our project will also produce valuable tools and reagents that will facilitate future studies aimed at understanding the devlopment of diverse bone minerlisation and soft tissue ossification abnormalities that include some diseases of great public health concern e.g osteoarthritis, osteoporosis and arterial calcification.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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