Award details

Evolution and genetic variation of avian toll - like receptor genes

Reference	BBS/E/R/00002769
Principal Investigator / Supervisor	Professor David Burt
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	9,785
Status	Completed
Type	Institute Project
Start date	01/10/2004
End date	30/09/2007
Duration	36 months

Abstract

Summary of student's research project: TLR genes are candidate genes for disease-resistance in livestock species, however our knowledge is poor concerning the number of loci, allelic variation in birds. We will use genomics and bioinfonnatics to determine the structure and evolution of the Toll-receptor gene family in poultry (chicken, turkey and ducks). This will be combined with mapping methods to detennine the location of these genes in these species. Comparisons between birds and mammals will indicate the extent of conservation between and within these genera. To assess the variation within these genes within a species, we will survey naturally occurring variation within specific turkey populations. Further analysis will define genes, which may be under positive selection. Advantageous alleles may increase fitness; we will test for an association between specific TLR alleIes and perfonnance traits in turkeys. Area of research

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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