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Role of SOCS2 in the growth retardation of chronic inflammatory disease
Reference
BBS/E/R/00001823
Principal Investigator / Supervisor
Professor Colin Farquharson
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
5,000
Status
Completed
Type
Institute Project
Start date
01/10/2007
End date
30/09/2010
Duration
36 months
Abstract
This project will examine the cellular and molecular mechanisms through which SOCS2 (suppressor of cytokine signalling 2) mediates bone growth and development. SOCS2 has primarily been associated with the negative regulation of growth hormone (GH) and insulin-like growth factor-1 (IGF-I) signalling, as seen by the high growth phenotype of mice lacking SOCS2. Studies investigating the regulatory mechanisms through which SOCS2 controls chondrocyte (cartilage cell) growth through both GH and IGF-I receptor signaling will form the basis of this project.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Immunology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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