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The expression and regulation of tribbles in bovine/theileria host pathogen interactions

Reference	BBS/E/R/00001619
Principal Investigator / Supervisor	Professor Elizabeth Glass
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	4,079
Status	Completed
Type	Institute Project
Start date	01/10/2007
End date	31/01/2008
Duration	4 months

Abstract

Background: The tick-borne protozoan parasite Theileria annulata is of global economic importance as the causative agent of the cattle disease tropical theileriosis. Over 250 million cattle, (around one sixth of the World population), across Europe, Asia and Africa, are at risk of infection. Most pathology caused by the disease is associated with the schizont stage of the parasite, which resides primarily within bovine macrophages, immune cells that should recognize and destroy the parasite. T. annulata alters the phenotype and function of the infected macrophage, altering the expression of host immunomodulatory molecules and in addition, inducing host cell proliferation. The tribbles gene family (Trb) have recently been identified as key regulators of inflammation as well as proliferation. Hypothesis: Trb play a key role in host-pathogen interactions and as T. annulata targets the intracellular pathways controlled by Trb, we propose that Trb may play an important role in the severe dysregulation of the inflammatory response in susceptible cattle. Research at Roslin: We have preliminary data that suggest that Trb are regulated during T. annulata infection.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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