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Investigation of the role of primary cilia during signalling events in development using the chicken mutant talpid 3

Reference	BBS/E/R/00001614
Principal Investigator / Supervisor	Dr Megan Davey
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	52,219
Status	Completed
Type	Institute Project
Start date	01/01/2008
End date	31/12/2009
Duration	24 months

Abstract

Talpid3 is an embryonically lethal chicken mutation. The phenotype is pleiotropic and includes limb polydactyly (many digits), facial and vascular defects and failure to form bone. We will build on recent progress in mapping the talpid3 mutation and identify the talpid3 gene. This gene is of fundamental importance because in this mutant all Hedgehog signalling is disrupted. Hedgehogs are a major class of extracellular signalling molecules, implicated in cell differentiation and survival both in embryos and tumours. Talpid3 limbs have many digits with no anterior-posterior pattern. We will exploit chicken genome resources and microarray technology to make comprehensive comparison of patterns of gene expression in normal and talpid3 limb buds. This will identify target genes downstream of the talpid3 gene and also identify new genes involved in anterior-posterior limb patterning.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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