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Methodology for high throughput characterization of loci controlling complex traits in livestock

Reference	BBS/E/R/00001606
Principal Investigator / Supervisor	Professor Dirk De Koning
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	88,924
Status	Completed
Type	Institute Project
Start date	01/06/2007
End date	30/09/2008
Duration	16 months

Abstract

Methodology for high throughput characterization of loci controlling complex traits in livestock QTL mapping designs in livestock are moving from experimental crosses towards general pedigrees. The traits under study are diverging from traditional production traits to include disease traits as well as levels of RNA expression. The combined study of genomic and gene-expression data offers exciting opportunities but is currently limited to model species using simple genetic models. We will develop and implement high throughput analytical tools for the detection of interacting genomic loci affecting RNA abundance levels. For general pedigrees, the variance component models will be extended to accommodate different genetical models and implemented for ongoing experiments. This project will be embedded within ongoing research at the Roslin Institute while new collaborations will arise through the analysis of micro-array data and commercial lines.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	Animal Health
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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