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Molecular mechanisms regulating folicle growth in cattle
Reference
BBS/E/R/00001600
Principal Investigator / Supervisor
Dr David Armstrong
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
78,590
Status
Completed
Type
Institute Project
Start date
01/10/2006
End date
31/03/2007
Duration
6 months
Abstract
Granulosa cell differentiation is a critical component of the process of follicle selection through which one or a few follicles are selected to become ovulatory during an oestrous/menstrual cycle. Ovarian and systemic changes associated with the process of selection in monovular farm species have been characterized in detail and have been likened to those occurring in humans. Specific ovarian molecules and genes involved in the selection process have been identified in vivo. A granulosa cell phenotype comparable to that occurring in selected follicles can be induced in vitro by treating immature granulosa cells with FSH and IGF-1. We will investigate the molecular mechanisms regulating granulose cell differentiation focusing on specifoc intracellular signaling pathways and the role of miRNAs.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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