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Regulation of embryonic stem cell growth and differentiation
Reference
BBS/E/R/00000898
Principal Investigator / Supervisor
Dr Thomas Burdon
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
11,400
Status
Completed
Type
Institute Project
Start date
01/10/2006
End date
30/09/2010
Duration
48 months
Abstract
Embryonic stem (ES) cells are pluripotent, immortal cell lines that can under appropriate circumstances differentiate into all somatic cell types. This extraordinary property means that ES cells represent a potentially inexhaustible source of normal cells for studying biological processes, drug discovery and cell-based therapies. However, the adverse effects of long-term culture on the potency and safety of these cell lines is a severe limitation to the realisation of their potential. To improve our ability to generate and reliably propagate ES cell lines, particularly human ES cells, it is essential that we understand better the growth properties of these unique cells in culture. This project willl investigate the growth requirements and underlying regulatory mechanisms of ES cells propagated in chemically defined media. The work will be underpinned by ES cell expertise at both Roslin Institute and Stem cell Sciences UK Ltd and will be jointly supervised by Tom Burdon at roslin Institute and Professor Ian Wilmut at the Centre for Regenerative Medicine,University of Edinburgh.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
Stem Cells
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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