Award details

The structure and role of the GnRH receptor in avian species

Reference	BBS/E/R/00000889
Principal Investigator / Supervisor	Professor Ian Dunn
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	15,283
Status	Completed
Type	Institute Project
Start date	01/12/2005
End date	30/11/2009
Duration	48 months

Abstract

It is proposed that the project will comprise two main components. On one hand bioinformatics techniques will be used to probe the evolutionary relationship of the receptor to those in other species and the structural properties of the receptor will be examined. Two obvious receptors one previously studied in this laboratory and another as yet unstudied exist on chromosome 10 of the chicken. The genome will be examined for other potential receptors related to GnRH using a number of homology search methods. This is of importance because there is evidence that the GnRH receptor has evolved rapidly in mammals, which may be related to specific aspects of their reproductive statagy. No efforts have been made to understand the evolution of avian receptors, and the second receptor may yield important information on how the evolution of avian receptors is involved in there breeding stratagies. The aspect that will form the second theme of the project is the distribution of the different receptor forms in the chicken. This will be combined with an examination of levels of expression in different pyhsiological situations appropriate to understanding the role of the receptors. This approach may include studies to locate the cell types in which expression of the different receptor occurs. Using a combination of in-vitro and in vivo techniques attempts will be made to determine the second messenger systems through which the receptors signal and what the ligand specificity of the second receptor is. The main signalling pathway is normally through PLC but there are a number of other potential signalling methods that have been proposed for the type II receptors.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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