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Role of growth arrest specific (GAS) genes in chondorcyte development and longitudinal bone growth

Reference	BBS/E/R/00000887
Principal Investigator / Supervisor	Professor Colin Farquharson
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	6,450
Status	Completed
Type	Institute Project
Start date	01/10/2005
End date	30/09/2009
Duration	48 months

Abstract

growth arrest specific (GAS) genes are a gene family that were initially identified due to their high expression in 3T3 fibroblasts following growth arrest. The precise role of the Gas proteins during bone growth is unclear and the proposed research will aim to determine if Gas proteins (in particular Gas 2, 6 and 7) regulate key chondrocyte activities such as prolifieration, differentiation apoptosis and minerlisation. Their relationship with established regulators of cell cycle control (p21 and p53) will also be investigated.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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