Award details

Molecular mechanisms regulating follicle growth in cattle

ReferenceBBS/E/R/00000670
Principal Investigator / Supervisor Dr David Armstrong
Co-Investigators /
Co-Supervisors
Institution The Roslin Institute
DepartmentThe Roslin Institute Department
Funding typeResearch
Value (£) 547,009
StatusCompleted
TypeInstitute Project
Start date 01/04/2002
End date 30/09/2006
Duration54 months

Abstract

Understanding mechanisms regulating folliculogenesis is a key aspect in the design of procedures for regulating animal production systems. This programme of work addresses this issue by providing information on molecular mechanisms regulating two key events in the life of a follicle, namely the initial recruitment of a primordial follicle into the growing pool and the selection of a dominant follicle. Genes involved in regulating these events will be identified using DNA microarrays and PCR based cDNA subtraction libraries. Once identified the genes will be characterised by in situ hybridization and the regulation of their expression examined in primary cultures of granulosa and theca cells. The identification of new genes regulating folliculogenesis is a central theme of this proposal, their identification will open up opportunities for the development of novel technologies for controlling reproduction.

Summary

unavailable
Committee Closed Committee - Animal Sciences (AS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
terms and conditions of use (opens in new window)
export PDF file