Award details

Functional genomics of avian reproductive neuroendocrinology

Reference	BBS/E/R/00000667
Principal Investigator / Supervisor	Professor Peter Sharp
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	The Roslin Institute Department
Funding type	Research
Value (£)	253,700
Status	Completed
Type	Institute Project
Start date	01/04/2002
End date	31/03/2005
Duration	36 months

Abstract

The objective of this proposal is to increase understanding of neuroendocrine mechanisms that depress the function of gonadotrophin releasing hormone neurones in poultry. The ARK genomics chicken neuroendocrine hypothalamic cDNA microarray will be expanded by the addition of cDNAs derived from the chicken hypothalamus enriched to represent genes involved in the depression of GnRH neuronal function. These will be obtained from a subtractive hypothalamic EST library derived from laying and incubating hens. A profile of genes showing changes in expression will be obtained by interrogating the microarray using labeled cDNA representing hypothalamic mRNA from laying and incubating hens QTL for incubation behaviour will be identified and comparative genomics will be used to establish whether genes showing changes in expression on the microarray are present at the QTL

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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