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Isolation and characterization of stem cell-derived human somatic progenitor cells for therapeutic application
Reference
BBS/E/R/00000666
Principal Investigator / Supervisor
Dr James McWhir
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
939,554
Status
Completed
Type
Institute Project
Start date
01/04/2002
End date
30/09/2006
Duration
54 months
Abstract
Two of the immediate challenges in the development of human ES transplantation therapy are (1) characterization of progenitor cells for therapeutically relevant lineages and (2) development of defined culture media. (1)Functional engraftment in many applications will require transplantation of progenitor cells which subsequently differentiate in vivo. We propose to develop a general strategy for identification and purification of progenitor cells which we will exemplify in osteogenesis. (2) The present culture regime for hES cells involves the use of conditioned medium. We also seek to identify the factor(s) in conditioned medium which maintain the undifferentiated state. Finally, a component of the present proposal is to support the management of existing programmes within the group.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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