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Control of differentiation in stem cells
Reference
BBS/E/R/00000664
Principal Investigator / Supervisor
Dr Thomas Burdon
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
727,873
Status
Completed
Type
Institute Project
Start date
01/04/2001
End date
30/09/2006
Duration
66 months
Abstract
Efficient propagation of pluripotent stem cells in vitro is a basic requirement for the effective use of these remarkable cells in medicine and biotechnology. To better understand the molecular mechanisms that govern this process, we will study the regulation of embryonic stem (ES) cell self-renewal by the cytokine receptor gp130. We aim to identify signals and targets downstream of gp130 that regulate the survival and differentiation of mouse ES cells. Studies will initially focus on actions of the cytokine-induced transcription factor STAT3 and a novel ES cell-specific variant of the adaptor protein Gab1. A comparative analysis of these, and other, signaling pathways in human ES cells will assist the identification of generic mechanisms regulating stem cell self-renewal.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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